Statistical Assessment of Chromatographic Response Functions vs. Solvent Mixture Model
a₁x₁+a₂x₂+a₃x₃+a₄x₁x₂+a₅x₁x₃+a₆x₂x₃

RF	X1	X2	X3	L	C1	C2	C3	C4	C5
0	1	0	0	9.00	0.134	0.228	0.159	0.006	0.021
1	0	1	0	8.75	0.947	0.970	0.970	0.906	0.890
2	0	0	1	8.83	0.000	0.000	0.000	0.000	0.000
3	1	1	0	8.84	0.759	0.805	0.798	0.601	0.629
4	1	0	1	8.93	0.060	0.110	0.076	0.000	0.000
5	0	1	1	8.76	0.963	0.977	0.977	0.839	0.822
6	1	1	1	8.70	0.764	0.845	0.834	0.460	0.547
7	1	1	8	8.86	0.394	0.532	0.509	0.060	0.072
8	8	1	1	8.87	0.573	0.756	0.683	0.114	0.262
9	1	8	1	8.82	0.934	0.954	0.959	0.837	0.824
10	55	19	26	18.95	0.181	0.309	0.608	0.709	0.759

RFE	C1	C2	C3	C4	C5
0	0.134	0.228	0.159	0.006	0.021
1	0.947	0.970	0.970	0.906	0.890
2	0.000	0.000	0.000	0.000	0.000
3	0.759	0.805	0.798	0.601	0.629
4	0.060	0.110	0.076	0.000	0.000
5	0.963	0.977	0.977	0.839	0.822
6	0.672	0.708	0.697	0.539	0.544
7	0.271	0.284	0.279	0.220	0.215
8	0.289	0.364	0.317	0.156	0.173
9	0.997	1.022	1.024	0.895	0.890
10	0.438	0.491	0.465	0.311	0.322

No	Est	Exp
1	0.672	0.764
2	0.708	0.845
3	0.697	0.834
4	0.539	0.460
5	0.544	0.547
6	0.271	0.394
7	0.284	0.532
8	0.279	0.509
9	0.220	0.060
10	0.215	0.072
11	0.289	0.573
12	0.364	0.756
13	0.317	0.683
14	0.156	0.114
15	0.173	0.262
16	0.997	0.934
17	1.022	0.954
18	1.024	0.959
19	0.895	0.837
20	0.890	0.824
21	0.438	0.181
22	0.491	0.309
23	0.465	0.608
24	0.311	0.709
25	0.322	0.759

RSM	X1	X2	X3	L	C1-C2	C1-C3	C1-C4	C1-C5	C2-C3	C2-C4	C2-C5	C3-C4	C3-C5	C4-C5
0	1	0	0	9.00	1.570	0.427	2.729	2.217	1.442	5.882	4.960	4.312	3.493	0.528
1	0	1	0	8.75	0.635	0.833	1.108	1.042	0.000	2.074	1.647	2.872	2.000	0.322
2	0	0	1	8.83	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000
3	1	1	0	8.84	0.953	0.907	3.077	1.855	0.275	5.403	3.120	6.214	3.348	0.476
4	1	0	1	8.93	0.936	0.337	1.317	1.333	0.923	3.062	3.111	2.566	2.615	0.000
5	0	1	1	8.76	0.511	0.585	3.254	1.425	0.000	5.762	1.826	6.722	1.902	0.178
6	1	1	1	8.70	1.687	1.718	6.163	2.589	0.310	9.178	3.895	10.689	4.132	1.118
7	1	1	8	8.86	2.392	2.318	6.805	2.836	0.571	12.116	4.448	14.473	4.580	0.131
8	8	1	1	8.87	2.717	1.903	8.059	4.182	1.529	13.735	7.702	15.303	7.711	2.758
9	1	8	1	8.82	0.447	0.667	2.048	1.311	0.263	3.679	1.900	4.696	2.164	0.172
10	55	19	26	18.95	2.455	7.191	9.671	10.234	4.371	6.290	6.871	1.433	2.080	0.732

RSME	C1-C2	C1-C3	C1-C4	C1-C5	C2-C3	C2-C4	C2-C5	C3-C4	C3-C5	C4-C5
0	1.570	0.427	2.729	2.217	1.442	5.882	4.960	4.312	3.493	0.528
1	0.635	0.833	1.108	1.042	0.000	2.074	1.647	2.872	2.000	0.322
2	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000
3	0.953	0.907	3.077	1.855	0.275	5.403	3.120	6.214	3.348	0.476
4	0.936	0.337	1.317	1.333	0.923	3.062	3.111	2.566	2.615	0.000
5	0.511	0.585	3.254	1.425	0.000	5.762	1.826	6.722	1.902	0.178
6	0.822	0.673	2.973	1.688	0.372	5.439	2.847	6.092	2.885	0.196
7	0.325	0.231	1.279	0.696	0.191	2.403	1.176	2.646	1.140	0.008
8	1.328	0.560	2.758	2.058	1.076	5.597	4.316	4.918	3.501	0.387
9	0.685	0.857	2.392	1.426	0.010	4.220	2.101	5.276	2.465	0.322
10	1.046	0.613	2.702	1.819	0.722	5.228	3.523	5.292	3.228	0.225

No	Est	Exp
1	0.822	1.687
2	0.673	1.718
3	2.973	6.163
4	1.688	2.589
5	0.372	0.310
6	5.439	9.178
7	2.847	3.895
8	6.092	10.689
9	2.885	4.132
10	0.196	1.118
11	0.325	2.392
12	0.231	2.318
13	1.279	6.805
14	0.696	2.836
15	0.191	0.571
16	2.403	12.116
17	1.176	4.448
18	2.646	14.473
19	1.140	4.580
20	0.008	0.131
21	1.328	2.717
22	0.560	1.903
23	2.758	8.059
24	2.058	4.182
25	1.076	1.529
26	5.597	13.735
27	4.316	7.702
28	4.918	15.303
29	3.501	7.711
30	0.387	2.758
31	0.685	0.447
32	0.857	0.667
33	2.392	2.048
34	1.426	1.311
35	0.010	0.263
36	4.220	3.679
37	2.101	1.900
38	5.276	4.696
39	2.465	2.164
40	0.322	0.172
41	1.046	2.455
42	0.613	7.191
43	2.702	9.671
44	1.819	10.234
45	0.722	4.371
46	5.228	6.290
47	3.523	6.871
48	5.292	1.433
49	3.228	2.080
50	0.225	0.732

RFO	X1	X2	X3	L	SP5	SP6	SP7	SP8	SP9
0	1	0	0	9.00	0.006	0.021	0.134	0.159	0.228
1	0	1	0	8.75	0.890	0.906	0.947	0.970	0.970
2	0	0	1	8.83	0.000	0.000	0.000	0.000	0.000
3	1	1	0	8.84	0.601	0.629	0.759	0.798	0.805
4	1	0	1	8.93	0.000	0.000	0.060	0.076	0.110
5	0	1	1	8.76	0.822	0.839	0.963	0.977	0.977
6	1	1	1	8.70	0.460	0.547	0.764	0.834	0.845
7	1	1	8	8.86	0.060	0.072	0.394	0.509	0.532
8	8	1	1	8.87	0.114	0.262	0.573	0.683	0.756
9	1	8	1	8.82	0.824	0.837	0.934	0.954	0.959
10	55	19	26	18.95	0.181	0.309	0.608	0.709	0.759

RFOE	SP5	SP6	SP7	SP8	SP9
0	0.006	0.021	0.134	0.159	0.228
1	0.890	0.906	0.947	0.970	0.970
2	0.000	0.000	0.000	0.000	0.000
3	0.601	0.629	0.759	0.798	0.805
4	0.000	0.000	0.060	0.076	0.110
5	0.822	0.839	0.963	0.977	0.977
6	0.533	0.549	0.672	0.697	0.708
7	0.215	0.219	0.271	0.279	0.284
8	0.157	0.172	0.289	0.317	0.364
9	0.882	0.903	0.997	1.024	1.022
10	0.309	0.323	0.438	0.465	0.491

No	Est	Exp
1	0.533	0.460
2	0.549	0.547
3	0.672	0.764
4	0.697	0.834
5	0.708	0.845
6	0.215	0.060
7	0.219	0.072
8	0.271	0.394
9	0.279	0.509
10	0.284	0.532
11	0.157	0.114
12	0.172	0.262
13	0.289	0.573
14	0.317	0.683
15	0.364	0.756
16	0.882	0.824
17	0.903	0.837
18	0.997	0.934
19	1.024	0.954
20	1.022	0.959
21	0.309	0.181
22	0.323	0.309
23	0.438	0.608
24	0.465	0.709
25	0.491	0.759

RFD	X1	X2	X3	L	RFOdif
0	1	0	0	9.00	0.055
1	0	1	0	8.75	0.081
2	0	0	1	8.83	0.283
3	1	1	0	8.84	0.057
4	1	0	1	8.93	0.078
5	0	1	1	8.76	0.097
6	1	1	1	8.70	0.047
7	1	1	8	8.86	0.067
8	8	1	1	8.87	0.036
9	1	8	1	8.82	0.076
10	55	19	26	18.95	0.040

RFDE	RFOdif
0	0.055
1	0.081
2	0.283
3	0.057
4	0.078
5	0.097
6	0.057
7	0.183
8	0.044
9	0.064
10	0.046

No	Est	Exp
1	0.057	0.047
2	0.183	0.067
3	0.044	0.036
4	0.064	0.076
5	0.046	0.040

RSR	X1	X2	X3	L	RSreu
0	1	0	0	9.00	1.035
1	0	1	0	8.75	0.401
2	0	0	1	8.83	0.000
3	1	1	0	8.84	0.778
4	1	0	1	8.93	0.452
5	0	1	1	8.76	0.559
6	1	1	1	8.70	1.285
7	1	1	8	8.86	1.169
8	8	1	1	8.87	2.498
9	1	8	1	8.82	0.573
10	55	19	26	18.95	2.038

RSRE	RSreu
0	1.035
1	0.401
2	0.000
3	0.778
4	0.452
5	0.559
6	0.636
7	0.240
8	0.881
9	0.556
10	0.704

No	Est	Exp
1	0.636	1.285
2	0.240	1.169
3	0.881	2.498
4	0.556	0.573
5	0.704	2.038

QF	X1	X2	X3	L	RSmin
0	1	0	0	9.00	0.427
1	0	1	0	8.75	0.000
2	0	0	1	8.83	0.000
3	1	1	0	8.84	0.275
4	1	0	1	8.93	0.000
5	0	1	1	8.76	0.000
6	1	1	1	8.70	0.310
7	1	1	8	8.86	0.131
8	8	1	1	8.87	1.529
9	1	8	1	8.82	0.172
10	55	19	26	18.95	0.732

QFE	RSmin
0	0.427
1	0.000
2	0.000
3	0.275
4	0.000
5	0.000
6	0.075
7	-0.023
8	0.293
9	0.054
10	0.138

No	Est	Exp
1	0.075	0.310
2	-0.023	0.131
3	0.293	1.529
4	0.054	0.172
5	0.138	0.732

RSO	X1	X2	X3	L	RS5	RS6	RS7	RS8
0	1	0	0	9.00	0.528	2.217	0.427	1.442
1	0	1	0	8.75	0.322	1.108	0.833	0.000
2	0	0	1	8.83	0.000	0.000	0.000	0.000
3	1	1	0	8.84	0.476	1.855	0.907	0.275
4	1	0	1	8.93	0.000	1.317	0.337	0.923
5	0	1	1	8.76	0.178	3.254	0.585	0.000
6	1	1	1	8.70	1.118	2.589	1.718	0.310
7	1	1	8	8.86	0.131	2.836	2.318	0.571
8	8	1	1	8.87	2.758	4.182	1.903	1.529
9	1	8	1	8.82	0.172	2.048	0.447	0.263
10	55	19	26	18.95	2.455	4.371	1.433	0.732

RSOE	RS5	RS6	RS7	RS8
0	0.528	2.217	0.427	1.442
1	0.322	1.108	0.833	0.000
2	0.000	0.000	0.000	0.000
3	0.476	1.855	0.907	0.275
4	0.000	1.317	0.337	0.923
5	0.178	3.254	0.585	0.000
6	0.196	2.487	0.673	0.372
7	0.008	1.271	0.231	0.191
8	0.387	2.121	0.560	1.076
9	0.322	2.042	0.857	0.010
10	0.225	2.163	0.613	0.722

No	Est	Exp
1	0.196	1.118
2	2.487	2.589
3	0.673	1.718
4	0.372	0.310
5	0.008	0.131
6	1.271	2.836
7	0.231	2.318
8	0.191	0.571
9	0.387	2.758
10	2.121	4.182
11	0.560	1.903
12	1.076	1.529
13	0.322	0.172
14	2.042	2.048
15	0.857	0.447
16	0.010	0.263
17	0.225	2.455
18	2.163	4.371
19	0.613	1.433
20	0.722	0.732

DCN	X1	X2	X3	L	DCcnt
0	1	0	0	9.00	5
1	0	1	0	8.75	4
2	0	0	1	8.83	1
3	1	1	0	8.84	5
4	1	0	1	8.93	4
5	0	1	1	8.76	3
6	1	1	1	8.70	5
7	1	1	8	8.86	4
8	8	1	1	8.87	5
9	1	8	1	8.82	4
10	55	19	26	18.95	5

DCNE	DCcnt
0	5.000
1	4.000
2	1.000
3	5.000
4	4.000
5	3.000
6	4.222
7	2.200
8	5.000
9	4.160
10	4.650

No	Est	Exp
1	4.222	5
2	2.200	4
3	5.000	5
4	4.160	4
5	4.650	5

RSA	X1	X2	X3	L	RSavg
0	1	0	0	9.00	1.153
1	0	1	0	8.75	0.566
2	0	0	1	8.83	0.000
3	1	1	0	8.84	0.878
4	1	0	1	8.93	0.644
5	0	1	1	8.76	1.004
6	1	1	1	8.70	1.434
7	1	1	8	8.86	1.464
8	8	1	1	8.87	2.593
9	1	8	1	8.82	0.733
10	55	19	26	18.95	2.248

RSAE	RSavg
0	1.153
1	0.566
2	0.000
3	0.878
4	0.644
5	1.004
6	0.932
7	0.425
8	1.035
9	0.807
10	0.931

No	Est	Exp
1	0.932	1.434
2	0.425	1.464
3	1.035	2.593
4	0.807	0.733
5	0.931	2.248

RSS	X1	X2	X3	L	RSsum
0	1	0	0	9.00	4.61
1	0	1	0	8.75	2.26
2	0	0	1	8.83	0.00
3	1	1	0	8.84	3.51
4	1	0	1	8.93	2.58
5	0	1	1	8.76	4.02
6	1	1	1	8.70	5.73
7	1	1	8	8.86	5.86
8	8	1	1	8.87	10.37
9	1	8	1	8.82	2.93
10	55	19	26	18.95	8.99

RSSE	RSsum
0	4.610
1	2.260
2	0.000
3	3.510
4	2.580
5	4.020
6	3.730
7	1.703
8	4.142
9	3.229
10	3.725

No	Est	Exp
1	3.730	5.73
2	1.703	5.86
3	4.142	10.37
4	3.229	2.93
5	3.725	8.99

QN	X1	X2	X3	L	sqNeff
0	1	0	0	9.00	89.55
1	0	1	0	8.75	108.70
2	0	0	1	8.83	114.68
3	1	1	0	8.84	83.79
4	1	0	1	8.93	103.84
5	0	1	1	8.76	79.28
6	1	1	1	8.70	71.90
7	1	1	8	8.86	59.46
8	8	1	1	8.87	71.24
9	1	8	1	8.82	80.92
10	55	19	26	18.95	63.38

QNE	sqNeff
0	89.550
1	108.700
2	114.680
3	83.790
4	103.840
5	79.280
6	83.857
7	101.136
8	88.326
9	92.174
10	87.895

No	Est	Exp
1	83.857	71.90
2	101.136	59.46
3	88.326	71.24
4	92.174	80.92
5	87.895	63.38

RSP	X1	X2	X3	L	RSvQN
0	1	0	0	9.00	20.6
1	0	1	0	8.75	8.3
2	0	0	1	8.83	0.0
3	1	1	0	8.84	16.8
4	1	0	1	8.93	9.9
5	0	1	1	8.76	20.3
6	1	1	1	8.70	31.9
7	1	1	8	8.86	39.4
8	8	1	1	8.87	58.2
9	1	8	1	8.82	14.5
10	55	19	26	18.95	56.7

RSPE	RSvQN
0	20.600
1	8.300
2	0.000
3	16.800
4	9.900
5	20.300
6	17.678
7	8.024
8	18.580
9	14.604
10	16.852

No	Est	Exp
1	17.678	31.9
2	8.024	39.4
3	18.580	58.2
4	14.604	14.5
5	16.852	56.7

RRP	X1	X2	X3	L	RSrpr
0	1	0	0	9.00	0.156
1	0	1	0	8.75	0.000
2	0	0	1	8.83	0.000
3	1	1	0	8.84	0.063
4	1	0	1	8.93	0.000
5	0	1	1	8.76	0.000
6	1	1	1	8.70	0.269
7	1	1	8	8.86	0.084
8	8	1	1	8.87	3.236
9	1	8	1	8.82	0.014
10	55	19	26	18.95	1.252

RRPE	RSrpr
0	0.156
1	0.000
2	0.000
3	0.063
4	0.000
5	0.000
6	0.011
7	-0.010
8	0.095
9	0.008
10	0.035

No	Est	Exp
1	0.011	0.269
2	-0.010	0.084
3	0.095	3.236
4	0.008	0.014
5	0.035	1.252

IEnt	X1	X2	X3	L	Entro
0	1	0	0	9.00	8.00
1	0	1	0	8.75	11.61
2	0	0	1	8.83	11.61
3	1	1	0	8.84	8.00
4	1	0	1	8.93	11.61
5	0	1	1	8.76	11.61
6	1	1	1	8.70	4.00
7	1	1	8	8.86	4.00
8	8	1	1	8.87	2.00
9	1	8	1	8.82	11.61
10	55	19	26	18.95	4.75

IEntE	Entro
0	8.000
1	11.610
2	11.610
3	8.000
4	11.610
5	11.610
6	10.407
7	11.754
8	8.722
9	10.744
10	9.902

No	Est	Exp
1	10.407	4.00
2	11.754	4.00
3	8.722	2.00
4	10.744	11.61
5	9.902	4.75

IEne	X1	X2	X3	L	Energ
0	1	0	0	9.00	8
1	0	1	0	8.75	0
2	0	0	1	8.83	0
3	1	1	0	8.84	8
4	1	0	1	8.93	0
5	0	1	1	8.76	0
6	1	1	1	8.70	16
7	1	1	8	8.86	16
8	8	1	1	8.87	18
9	1	8	1	8.82	0
10	55	19	26	18.95	14

IEneE	Energ
0	8.000
1	0.000
2	0.000
3	8.000
4	0.000
5	0.000
6	2.667
7	-0.320
8	6.400
9	1.920
10	3.784

No	Est	Exp
1	2.667	16
2	-0.320	16
3	6.400	18
4	1.920	0
5	3.784	14